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ProductsBack/GCN1L1 Polyclonal Antibody

Western blot analysis of extracts from wild type(WT) and GCN1L1 knockout (KO) 293T(KO) cells using GCN1L1 Polyclonal Antibody at 1:3000 dilution.

Western blot analysis of extracts from wild type(WT) and GCN1L1 knockout (KO) 293T(KO) cells using GCN1L1 Polyclonal Antibody at 1:3000 dilution.

Western blot analysis of extracts from wild type(WT) and GCN1L1 knockout (KO) 293T(KO) cells using GCN1L1 Polyclonal Antibody at 1:3000 dilution.

GCN1L1 Polyclonal Antibody

E-AB-64442

Product group Antibodies

Overview

Supplier
Elabscience
Product Name
GCN1L1 Polyclonal Antibody
Delivery Days Customer
12
Certification
Research Use Only
Scientific Description
Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1 on Ser-52, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion.
UNSPSC
12352203

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