GCN2iB (acetate) [2183470-13-3]
HY-112654A
CAS Number2183470-13-3
Product group Chemicals
Molecular Weight511.89
Overview
- SupplierMedChem Express
- Product NameGCN2iB (acetate) [2183470-13-3]
- Delivery Days Customer9
- CAS Number2183470-13-3
- CertificationResearch Use Only
- Molecular FormulaC20H16ClF2N5O5S
- Molecular Weight511.89
- Scientific DescriptionGCN2iB acetate is a GCN2 inhibitor that enhances Gcn2 activity and Atf4 expression. GCN2iB can activate Gcn2 mutants lacking functional regulatory regions or certain kinase domain substitution mutants. GCN2iB increases eIF2 phosphorylation by Gcn2 at low concentrations, thereby enhancing the cellular response to nutritional stress. GCN2iB may have potential benefits for the inhibition of cancer cells expressing low basal levels of aspartate synthetase, enhancing their sensitivity to the anti-leukemic compound L-aspartase[1].
- SMILESO=S(C1=CC(Cl)=CN=C1OC)(NC2=CC=C(C(C#CC3=CN=C(N=C3)N)=C2F)F)=O.CC(O)=O
- UNSPSC12352200