GDC-0623

AbMole BioScience

GDC-0623

9

1168091-68-6

Research Use Only

456.21

GDC-0623 (RG 7421) is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM, +ATP), and displays 6-fold weaker potency against HCT116 (KRAS (G13D), EC50=42 nM) versus A375 (BRAFV600E, EC50=7 nM).

OCCONC(=O)C1=C(NC2=C(F)C=C(I)C=C2)[N]3C=NC=C3C=C1

12352200