Bio-Connect

GDC-0623

M14169
AbMole BioScience
CAS Number1168091-68-6
Product group Chemicals
Molecular Weight456.21
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Overview

  • Supplier
    AbMole BioScience
  • Product Name
    GDC-0623
  • Delivery Days Customer
    9
  • CAS Number
    1168091-68-6
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Molecular Weight
    456.21
  • Scientific Description
    GDC-0623 (RG 7421) is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM, +ATP), and displays 6-fold weaker potency against HCT116 (KRAS (G13D), EC50=42 nM) versus A375 (BRAFV600E, EC50=7 nM).
  • SMILES
    OCCONC(=O)C1=C(NC2=C(F)C=C(I)C=C2)[N]3C=NC=C3C=C1
  • UNSPSC
    12352200

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