GDNF Polyclonal Antibody

Reddot Biotech

GDNF Polyclonal Antibody

5

ImmunoHistoChemistry

Research Use Only

Polyclonal

80 ug/ml

Unconjugated

Gdnf

glial cell line derived neurotrophic factor

AI385739; astrocyte-derived trophic factor; ATF; glial cell line-derived neurotrophic factor; neurotrophic factor

Rabbit

IgG

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing.

Mouse, Rat

-20°C

12352203