GeA-69

MedChem Express

GeA-69 [2143475-98-1]

10

2143475-98-1

Research Use Only

99.91

C20H16N2O

300.35

GeA-69 is a selective, allosteric inhibitor of poly-adenosine-diphosphate-ribose polymerase 14 ( PARP14 ) targeting macrodomain 2 ( MD2 ), with a K d value of 2.1 microM. GeA-69 involves in DNA damage repair mechanisms and prevents recruitment of PARP14 MD2 to sites of laser-induced DNA damage [1] [2] .

CC(NC1=CC=CC=C1C2=CC=CC3=C2NC4=C3C=CC=C4)=O

2°C to 8°C

12352200