Gefitinib (hydrochloride)

MedChem Express

Gefitinib (hydrochloride) [184475-55-6]

10

184475-55-6

Research Use Only

99.85

C22H25Cl2FN4O3

483.36

Gefitinib hydrochloride (ZD1839 hydrochloride) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC 50 of 33 nM. Gefitinib hydrochloride selectively inhibits EGF-stimulated tumor cell growth (IC 50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib hydrochloride also induces autophagy . Gefitinib hydrochloride has antitumour activity [1] [2] .

ClC1=C(C=CC(NC2=NC=NC3=C2C=C(C(OC)=C3)OCCCN4CCOCC4)=C1)F.[H]Cl

2°C to 8°C

12352200