GFB-8438

MedChem Express

GFB-8438 [2304549-73-1]

9

2304549-73-1

Research Use Only

99.74

C16H14ClF3N4O2

386.76

GFB-8438 is a potent and subtype selective TRPC5 inhibitor, with IC 50 s of 0.18 and 0.29 microM of hTRPC5 and hTRPC4, respectively. GFB-8438 shows excellent selectivity against TRPC6, other TRP family members, NaV 1.5, as well as limited activity against the hERG channel. GFB-8438 protects mouse podocytes from injury induced by protamine sulfate model [1] .

O=C1CN(C2=C(Cl)C(NN=C2)=O)CCN1CC3=CC=CC=C3C(F)(F)F

-20°C,2°C to 8°C

12352200