GFR alpha 3 peptide

GeneTex

GFR alpha 3 peptide

9

The peptide is used for blocking the activity of anti-GFRa-3 (cat. no 8028). Incubating the peptide with equal volume of antibody for 30 min at 37C usually completely blocks the antibody activity in Western blotting.

Neutralisation/Blocking

Research Use Only

0.20 mg/ml

Unconjugated

Members of the glial cell line-derived neurotrophic factor (GDNF) family including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novelglycosylphosphadidylinositol linked protein GFRa and Ret receptor tyrosine kinase GFRb. Following the discovery of GFRa-1 and -2, a novel receptor in GFRa family was identified recently in human and mouse and designated GFRa-3. GFRa-3 binds persephin, thus, persephin, GFRa-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.

-20°C

12352202