GGTI-2147 [191102-87-1]

MedChem Express

GGTI-2147 [191102-87-1]

14

191102-87-1

Research Use Only

C28H30N4O3

470.56

GGTI-2147 is a potent GGTase I inhibitor. GGTI-2147 blocks geranyl-geranylation of Rap1A and reduces the activity of Rac1 (one of substrates for GGTI) and ameliorates the OGD/R-induced neuronal apoptosis.GGTI-2147 can be used for neurodevelopmental disorders research, such as autism, depression, and schizophrenia[1].

CC(C)C[C@@H](C(OC)=O)NC(C1=CC=C(NCC2=CN=CN2)C=C1C3=C4C=CC=CC4=CC=C3)=O

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