GGTI-286 (hydrochloride) [181141-66-2]

MedChem Express

GGTI-286 (hydrochloride) [181141-66-2]

10

181141-66-2

Research Use Only

C23H32ClN3O3S

466.04

GGTI-286 hydrochloride, a potent GGTase I inhibitor, is 25-fold more potent (IC50=2 microM) than the corresponding methyl ester of FTI-276 (HY-15873A). GGTI-286 hydrochloride selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s =2 and >30 microM, respectively). GGTI-286 hydrochloride also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 microM[1][2].

CC(C)C[C@@H](C(OC)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=CC=CC=C2)=O.[H]Cl

12352200