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Chemical Structure
Chemical Structure
Chemical Structure

Gimeracil [103766-25-2]

CDX-G0209
Chemodex
CAS Number103766-25-2
Product group Chemicals
Estimated Purity>99%
Molecular Weight145.54
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Overview

  • Supplier
    Chemodex
  • Product Name
    Gimeracil [103766-25-2]
  • Delivery Days Customer
    10
  • CAS Number
    103766-25-2
  • Certification
    Research Use Only
  • Estimated Purity
    >99%
  • Hazard Information
    Warning
  • Molecular Formula
    C5H4ClNO2
  • Molecular Weight
    145.54
  • Scientific Description
    Chemical. CAS: 103766-25-2. Formula: C5H4ClNO2. MW: 145.54. Gimeracil is an orally active inhibitor against dihydropyrimidine dehydrogenase (DPYD), the rate limiting enzyme for the catabolism of pyrimidines, including the chemotherapeutic drug 5-fluorouracil (5FU). It has been administered concomitantly with 5-fluorouracil in a chemotherapy regimen termed S-1 to block 5-fluorouracil degradation, thus prolonging circulating 5-fluorouracil concentrations. Furthermore, Gimeracil has been shown to inhibit homologous recombination in the repair of DNA double strand breaks, which can sensitize cancer cells to radiotherapy. - Gimeracil is an orally active inhibitor against dihydropyrimidine dehydrogenase (DPYD), the rate limiting enzyme for the catabolism of pyrimidines, including the chemotherapeutic drug 5-fluorouracil (5FU). It has been administered concomitantly with 5-fluorouracil in a chemotherapy regimen termed S-1 to block 5-fluorouracil degradation, thus prolonging circulating 5-fluorouracil concentrations. Furthermore, Gimeracil has been shown to inhibit homologous recombination in the repair of DNA double strand breaks, which can sensitize cancer cells to radiotherapy.
  • SMILES
    ClC1=CNC(C=C1O)=O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

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