Ginkgolic Acid (C13:0)

MedChem Express

Ginkgolic Acid (C13:0) [20261-38-5]

9

20261-38-5

Research Use Only

99.92

C20H32O3

320.47

Ginkgolic Acid (C13:0) is a natural anticariogenic agent in that it exhibits antimicrobial activity against S. mutans and suppresses the specific virulence factors associated with its cariogenicity. IC50 value: Inhibiting the biofilm formation of S. mutans (MBIC (50) = 4 microg/mL); reduced 1-day-developed biofilm of S. mutans by 50 % or more at low concentration (MBRC (50) = 32 microg/mL). Target: In vitro: Ginkgolic Acid (C13:0) inhibited not only the growth of S. mutans planktonic cells at minimum inhibitory concentration (MIC) of 4 microg/mL and minimum bactericidal concentration (MBC) of 8 microg/mL but also the acid production and adherence to saliva-coated hydroxyapatite of S. mutans at sub-MIC concentration. In addition, this agent was effective in inhibiting the biofilm formation of S. mutans (MBIC (50) = 4 microg/mL), and it reduced 1-day-developed biofilm of S. mutans by 50 % or more at low concentration (MBRC (50) = 32 microg/mL). Furthermore Ginkgolic Acid (C13:0) disrupted biofilm integrity effectively [1]. In vivo:

O=C(O)C1=C(CCCCCCCCCCCCC)C=CC=C1O

2°C to 8°C

12352200