Gint4.T aptamer (sodium)

MedChem Express

Gint4.T aptamer (sodium)

14

Research Use Only

Gint4.T aptamer sodium is a nuclease-resistant RNA aptamer-based antagonist targeting platelet-derived growth factor receptor beta (PDGFRbeta) (Kd: 9.6 nM). Gint4.T aptamer sodium inhibits PDGFRbeta heterodimerization and EGFR transactivation. It can significantly inhibit cell migration and proliferation, induce differentiation and prevent tumor growth in vivo. Gint4.T aptamer sodium specifically inhibits PDGFRbeta-mediated tropism of mesenchymal stem cells (MSCs) toward the tumor microenvironment[1].

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