GITR / Tnfrsf18 (Mouse)(DTA-1), 1mg/mL [26628-22-8]

Biotium

GITR / Tnfrsf18 (Mouse)(DTA-1), 1mg/mL [26628-22-8]

9

Functional Assay, Flow Cytometry

26628-22-8

Research Use Only

Monoclonal

DTA-1

1 mg/ml

HOS

Holt-Oram syndrome

TBX5

Mouse

IgG2b

Tumor necrosis factor receptor superfamily member 18

GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25 CD4 Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-B activation, and abrogate the inhibitory function ofCD25 CD4 Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.

Animal

Mouse

-20°C

41116161