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ProductsBack/GITR / Tnfrsf18 (Mouse)(DTA-1), CF405S conjugate, 0.1mg/mL [26628-22-8]

GITR / Tnfrsf18 (Mouse)(DTA-1), CF405S conjugate, 0.1mg/mL [26628-22-8]

BNC040976
Biotium
ApplicationsFunctional Assay, Flow Cytometry
Product group Antibodies
ReactivityBovine, Mouse
TargetHOS
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Overview

  • Supplier
    Biotium
  • Product Name
    GITR / Tnfrsf18 (Mouse)(DTA-1), CF405S conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Applications
    Functional Assay, Flow Cytometry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    DTA-1
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID3180
  • Target name
    HOS
  • Target description
    Holt-Oram syndrome
  • Target synonyms
    TBX5
  • Host
    Mouse
  • Isotype
    IgG2b
  • Protein IDO35714
  • Protein Name
    Tumor necrosis factor receptor superfamily member 18
  • Scientific Description
    GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25 CD4 Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-B activation, and abrogate the inhibitory function ofCD25 CD4 Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.
  • Source
    Animal
  • Reactivity
    Bovine, Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203