GK470 [1621517-53-0]
HY-120050
CAS Number1621517-53-0
Product group Chemicals
Molecular Weight389.51
Overview
- SupplierMedChem Express
- Product NameGK470 [1621517-53-0]
- Delivery Days Customer9
- CAS Number1621517-53-0
- CertificationResearch Use Only
- Molecular FormulaC21H27NO4S
- Molecular Weight389.51
- Scientific DescriptionGK470 (compound 28) is an inhibitor of group IVA cytosolic phospholipase A2 (GIVA cPLA2) with an IC50 of 300 nM in vesicle assays. GK470 has anti-inflammatory activity, inhibiting the release of arachidonic acid in SW982 fibroblast-like synoviocytes with an IC50 value of 0.6 microM. GK470 exhibits comparable anti-inflammatory effects to Methotrexate (HY-14519) in a preventive collagen-induced arthritis model and significantly reduces plasma PGE2 levels[1].
- SMILESO=C(OC)C1=CSC(C(COC2=CC=C(C=C2)CCCCCCCC)=O)=N1
- UNSPSC12352200