Glabridin [59870-68-7]

Chemodex

Glabridin [59870-68-7]

10

59870-68-7

Research Use Only

>98%

C20H20O4

324.37

Chemical. CAS: 59870-68-7. Formula: C20H20O4. MW: 324.37. Glabridin is a prenylated isoflavonoid found in licorice (Glycyrrhiza glabra L.) root extract that is reported to possess antiviral, antimicrobial, anti-inflammatory, antidiabetic, antiatherogenic, antioxidant, antitumor and estrogen-like properties. These diverse biological activities are largely related to the capacity of glabridin to down-regulate reactive oxygen species, bind to antioxidant effectors and act as a selective estrogen receptor modulator. On a molecular level it is, next to other targets, activating PPARgamma, inhibiting JNK1/2 and human carboxylesterase 2 (CES2A). Based on its antioxidant capacity it is also studied as an anti-aging cosmetic agent. Recently, it has been shown in docking experiments to have high binding affinity to the main protease of SARS-CoV-2. - Glabridin is a prenylated isoflavonoid found in licorice (Glycyrrhiza glabra L.) root extract that is reported to possess antiviral, antimicrobial, anti-inflammatory, antidiabetic, antiatherogenic, antioxidant, antitumor and estrogen-like properties. These diverse biological activities are largely related to the capacity of glabridin to down-regulate reactive oxygen species, bind to antioxidant effectors and act as a selective estrogen receptor modulator. On a molecular level it is, next to other targets, activating PPARgamma, inhibiting JNK1/2 and human carboxylesterase 2 (CES2A). Based on its antioxidant capacity it is also studied as an anti-aging cosmetic agent. Recently, it has been shown in docking experiments to have high binding affinity to the main protease of SARS-CoV-2.

CC1(C)C=CC2=C(C=CC3=C2OC[C@@H](C4=C(O)C=C(O)C=C4)C3)O1

RT

12352200