Glucagon antibody [K79bB10]

GeneTex

Glucagon antibody [K79bB10]

7

Monoclonal Anti-Glucagon reacts with pancreatic glucagon in RIA and immunocytochemistry. The affinity constant of 6.1 x 10(8) L/M in RIA. The antibody weakly cross-reacts with gut glucagon (enteroglucagon) in an immunohistological assay. Cross-reactivity

IHC-P: 1:2,000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Research Use Only

Monoclonal

K79bB10

Unconjugated

Liquid

GCG

glucagon

glicentin-related polypeptide; GLP1; GLP-1; GLP2; glucagon-like peptide 1; glucagon-like peptide 2; GRPP; preproglucagon; pro-glucagon

Mouse

IgG1

Glucagon

Glucagon is a 29-residue polypeptide hormone (MW 3482), produced in the pancreas. A related hormone, enteroglucagon (or oxyntomodulin), which is produced in the mucosa of the small and large intestine, consists of the 29 amino acid sequence of pancreatic glucagon extended by 8 additional residues at the C-terminus. The biological activities of pancreatic glucagon include glycogenolysis, lipolysis, gluconeogenesis, and ketogenesis, which are antagonistic effects to those of insulin action, thus leading to increased blood glucose levels. Immunocytochemical studies have revealed the presence of pancreatic glucagon inside the A or alpha cells, which constitute 15-20% of the islet cell population. These cells are located preferentially at the periphery of the human pancreatic islets. Pathological manifestations of the glucagon-type peptide reside almost exclusively with the existence of tumors or glucagonomas, as no states of glucagon-cell deficiency or hyperplasia have been identified. Glucagon-specific antibodies would prove useful as an cell and tumor markers applying immunohistochemical techniques, and as an analytical tool in quantification of the hormone.

-20°C or -80°C,2°C to 8°C

12352203