Glumetinib [1642581-63-2]

MedChem Express

Glumetinib [1642581-63-2]

10

1642581-63-2

Research Use Only

99.94

C21H17N9O2S

459.48

Glumetinib (SCC244) is a highly selective, orally bioavailable, ATP-competitive c-Met inhibitor with an IC50 of 0.42 nM. Glumetinib has greater than 2400-fold selectivity for c-Met over those 312 kinases evaluated, including the c-Met family member RON and highly homologous kinases Axl, Mer, TyrO3. Antitumor activity[1].

O=S(N1N=CC2=NC=C(C3=CN(C)N=C3)C=C21)(C4=CN=C5C=CC(C6=CN(C)N=C6)=CN54)=O

-20°C,2°C to 8°C

12352200