Glutaminyl cyclases-IN-1

MedChem Express

Glutaminyl cyclases-IN-1 [3032400-33-9]

5

Research Use Only

98.21

C25H30N6O2S

478.61

Glutaminyl cyclases-IN-1 (IsoQC-IN-1) is a potent glutaminyl cyclases (QC) inhibitor with IC50 values of 12 nM and 73 nM for human QC and isoQC, respectively. Glutaminyl cyclases-IN-1 can selectively interfere with the interaction of CD47/SIRPalpha through isoQC inhibition, and enhances the increased phagocytic activity of both THP-1 and U937 macrophages[1].

COC1=C(C=CC(CN2C=NC3=CC(C4=NN=C(S4)N)=CC=C32)=C1)OCCCN5CCCCC5

-20°C,2°C to 8°C

12131703