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Glycochenodeoxycholic acid [640-79-9]

Research Use Only
HY-N2334
MedChem Express
CAS Number640-79-9
Product group Chemicals
Estimated Purity98.0
Molecular Weight449.62
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Glycochenodeoxycholic acid [640-79-9]
  • Delivery Days Customer
    10
  • CAS Number
    640-79-9
  • Certification
    Research Use Only
  • Estimated Purity
    98.0
  • Molecular Formula
    C26H43NO5
  • Molecular Weight
    449.62
  • Scientific Description
    Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC)[1][2][3][4].
  • SMILES
    C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(NCC(O)=O)=O)([H])[C@@]3([H])[C@]([C@@]4([C@](C[C@H](O)CC4)([H])C[C@H]3O)C)([H])CC1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200