Glycochenodeoxycholic acid [640-79-9]

HY-N2334
Overview
- SupplierMedChem Express
- Product NameGlycochenodeoxycholic acid [640-79-9]
- Delivery Days Customer10
- CAS Number640-79-9
- CertificationResearch Use Only
- Estimated Purity98.0
- Molecular FormulaC26H43NO5
- Molecular Weight449.62
- Scientific DescriptionGlycochenodeoxycholic acid (Chenodeoxycholylglycine) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC)[1][2][3][4].
- SMILESC[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(NCC(O)=O)=O)([H])[C@@]3([H])[C@]([C@@]4([C@](C[C@H](O)CC4)([H])C[C@H]3O)C)([H])CC1
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200