Glypican 1 antibody [N3C3]
GTX104557
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetGPC1
Overview
- SupplierGeneTex
- Product NameGlypican 1 antibody [N3C3]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. FACS: 1:50-1:200. IP: 1:100-1:500. ELISA: 1:1000-1:10000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.71 mg/ml
- ConjugateUnconjugated
- Gene ID2817
- Target nameGPC1
- Target descriptionglypican 1
- Target synonymsglypican, glypican-1, epididymis secretory sperm binding protein, glypican proteoglycan 1
- HostRabbit
- IsotypeIgG
- Protein IDP35052
- Protein NameGlypican-1
- Scientific DescriptionCell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Munekage E, Serada S, Tsujii S, et al. A glypican-1-targeted antibody-drug conjugate exhibits potent tumor growth inhibition in glypican-1-positive pancreatic cancer and esophageal squamous cell carcinoma. Neoplasia. 2021,23(9):939-950. doi: 10.1016/j.neo.2021.07.006Read this paper
- Zhang J, Cui J, Li X, et al. Increased secretion of VEGF-C from SiO(2)-induced pulmonary macrophages promotes lymphangiogenesis through the Src/eNOS pathway in silicosis. Ecotoxicol Environ Saf. 2021,218:112257. doi: 10.1016/j.ecoenv.2021.112257Read this paper
- Kaur SP, Verma A, Lee HK, et al. Inhibition of glypican-1 expression induces an activated fibroblast phenotype in a human bone marrow-derived stromal cell-line. Sci Rep. 2021,11(1):9262. doi: 10.1038/s41598-021-88519-7Read this paper
- Emmanouilidi A, Paladin D, Greening DW, et al. Oncogenic and Non-Malignant Pancreatic Exosome Cargo Reveal Distinct Expression of Oncogenic and Prognostic Factors Involved in Tumor Invasion and Metastasis. Proteomics. 2019,19(8):e1800158. doi: 10.1002/pmic.201800158Read this paper
- Kim P, Scott MR, Meador-Woodruff JH. Abnormal ER quality control of neural GPI-anchored proteins via dysfunction in ER export processing in the frontal cortex of elderly subjects with schizophrenia. Transl Psychiatry. 2019,9(1):6. doi: 10.1038/s41398-018-0359-4Read this paper
- Lu H, Niu F, Liu F, et al. Elevated glypican-1 expression is associated with an unfavorable prognosis in pancreatic ductal adenocarcinoma. Cancer Med. 2017,6(6):1181-1191. doi: 10.1002/cam4.1064Read this paper
- Hsia K, Yang MJ, Chen WM, et al. Sphingosine-1-phosphate improves endothelialization with reduction of thrombosis in recellularized human umbilical vein graft by inhibiting syndecan-1 shedding in vitro. Acta Biomater. 2017,51:341-350. doi: 10.1016/j.actbio.2017.01.050Read this paper
- Huang G, Ge G, Izzi V, et al. α3 Chains of type V collagen regulate breast tumour growth via glypican-1. Nat Commun. 2017,8:14351. doi: 10.1038/ncomms14351Read this paper
- Bologna-Molina R, Mosqueda-Taylor A, Molina-Frechero N. Differential expression of glypican-1 in ameloblastoma variants. Appl Immunohistochem Mol Morphol. 2015,23(2):153-60. doi: 10.1097/PAI.0000000000000042Read this paper
Datasheet
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