GMA-839 [162882-76-0]

MedChem Express

GMA-839 [162882-76-0]

9

162882-76-0

Research Use Only

C21H31F3O3

388.46

GMA-839 is a selective modulator of the gamma-aminobutyric acid A receptor (GABAA) with an IC50 value of 230 nM. GMA-839 exhibits potent anxiolytic-like activity, demonstrating significant dose-dependent anxiolytic effects in animal models, with an effective oral dose of 1.6 mg/kg. Significant increases in punished responding were observed in squirrel monkeys and pigeons. GMA-839 shows promise for research in the field of anxiolytics[1].

FC(F)(F)[C@]1(CC[C@@]2([C@]3(CC[C@@]4([C@H](CC[C@]4([C@@]3(CC[C@@]2(C1)[H])[H])[H])C(CO)=O)C)[H])[H])O

12352200