GNAS Polyclonal Antibody

Reddot Biotech

GNAS Polyclonal Antibody

5

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

0.4 mg/ml

Unconjugated

GNAS

GNAS complex locus

adenylate cyclase-stimulating G alpha protein; AHO; alternative gene product encoded by XL-exon; C20orf45; extra large alphas protein; G protein subunit alpha S; GNAS1; GPSA; GSA; GSP; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; guanine nucleotide regulatory protein; NESP; PITA3; POH; protein ALEX; protein GNAS; protein SCG6 (secretogranin VI); SCG6; secretogranin VI; SgVI

Rabbit

IgG

This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5 exons. Some transcripts contain a differentially methylated region (DMR) at their 5 exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses.

-20°C

12352203