GNE-0439 [1241902-40-8]

MedChem Express

GNE-0439 [1241902-40-8]

10

1241902-40-8

Research Use Only

99.80

C21H31NO3

345.48

GNE-0439 is a novel Nav1.7-selective inhibitor with IC50 of 0.34 uM and inhibits Nav1.5 with an IC50 of 38.3 microM. GNE-0439 inhibits mutant N1742K channels (IC50=0.37 uM) in membrane potential assays. GNE-0439 possesses a carboxylic acid group, binds outside of the channel pore, and is unique compared with known selective VSD4 binders[1].

CC(C)[C@@H](C(O)=O)NC(C1=CC=C(C2CCC(CCC)CC2)C=C1)=O

2°C to 8°C

12352200