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ProductsBack/GNE-7883 [2648450-42-2]

GNE-7883 [2648450-42-2]

HY-147214
MedChem Express
CAS Number2648450-42-2
DownloadMSDS
Product group Chemicals
Estimated Purity99.54
Molecular Weight500.57
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Overview

  • Supplier
    MedChem Express
  • Product Name
    GNE-7883 [2648450-42-2]
  • Delivery Days Customer
    5
  • CAS Number
    2648450-42-2
  • Certification
    Research Use Only
  • Estimated Purity
    99.54
  • Molecular Formula
    C28H29FN6O2
  • Molecular Weight
    500.57
  • Scientific Description
    GNE-7883 is a pan-TEAD inhibitor that blocks the association of YAP/TAZ with TEAD. GNE-7883 effectively reduces chromatin accessibility at TEAD motifs, inhibits cell proliferation in multiple cell line models, and achieves strong anti-tumor efficacy in vivo. In addition, GNE-7883 effectively overcomes intrinsic and acquired resistance to KRAS (Kirsten rat sarcoma viral oncogene homolog) G12C inhibitors in multiple preclinical models by inhibiting YAP/TAZ activation[1][2][3].
  • SMILES
    O=C(C=C(C1=CC=C(C2CCCCC2)C=C1)N3)N4C3=C(C(N5CC(CF)C5)=O)C(C6=NC=CN=C6C)=N4
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12131703