GNF7156, beta Cell Proliferation Inducer [2041071-54-7] [2041071-54-7]
BS-60293C
CategoryCell Culture Media Reagents
Product group Cell Culture
Overview
- SupplierBioss
- Product NameGNF7156, beta Cell Proliferation Inducer [2041071-54-7] [2041071-54-7]
- Delivery Days Customer16
- CAS Number2041071-54-7
- CertificationResearch Use Only
- ConjugateUnconjugated
- Estimated Purity98 - 98.0
- Molecular FormulaC22 H22 N6 O3
- Molecular Weight418.45
- Scientific DescriptionGNF7156 is a highly potent and selective small molecule that promotes pancreatic beta cell proliferation in rodent (EC50 ~2.2 microM) and human primary islets (EC50 ~0.76 microM). It acts most likely as a result of combined inhibition of DYRK1A and GSK3B. GNF7156-treated human islets retain functionality in vitro and after transplantation into diabetic mice. Oral dosing of GNF7156 in diabetic mice induces beta-cell proliferation, increases beta-cell mass and insulin content, and improves glycaemic control. Biochemical, genetic and cell biology data point to Dyrk1a as the key molecular target. GNF7156 is a good chemical tool to support the feasibility of treating diabetes with an oral therapy to restore beta-cell mass, and highlights a tractable pathway for future drug discovery efforts.
- SMILESNC1=NC=C(N=C1C(=O)NC1C=NC=CC=1N1CCC(CC1)C(O)=O)C1C=CC=CC=1
- Storage Instruction-20°C
- UNSPSC41106200