GNF7156, beta Cell Proliferation Inducer

Bioss Antibodies

GNF7156, beta Cell Proliferation Inducer

16

Research Use Only

GNF7156 is a highly potent and selective small molecule that promotes pancreatic beta cell proliferation in rodent (EC50 ~2.2 microM) and human primary islets (EC50 ~0.76 microM). It acts most likely as a result of combined inhibition of DYRK1A and GSK3B. GNF7156-treated human islets retain functionality in vitro and after transplantation into diabetic mice. Oral dosing of GNF7156 in diabetic mice induces beta-cell proliferation, increases beta-cell mass and insulin content, and improves glycaemic control. Biochemical, genetic and cell biology data point to Dyrk1a as the key molecular target. GNF7156 is a good chemical tool to support the feasibility of treating diabetes with an oral therapy to restore beta-cell mass, and highlights a tractable pathway for future drug discovery efforts.

-20°C

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