Go 7874 [153207-86-4]

MedChem Express

Go 7874 [153207-86-4]

5

153207-86-4

Research Use Only

C27H26N4O4

470.52

Go 7874 is a protein kinase C (PKC) inhibitor. Go 7874 mediated neuroprotection against LPS/IFNg-induced neuronal cell death in an immune-mediated neurotoxicity model, not through PKC activity. In contrast, the neuroprotective mechanism of Go 7874 involves inhibition of inducible nitric oxide synthase (iNOS) gene expression, followed by reduced nitric oxide (NO) production[1].

O=C1NC(C2=C1C3=C(N(C4=C3C=C(C=C4)OC)CC(CN(C)C)O)C5=C2C6=C(C=CC=C6)N5C)=O

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