GOT1 inhibitor-1

MedChem Express

GOT1 inhibitor-1 [732973-87-4]

10

732973-87-4

Research Use Only

99.45

C19H19ClN4O

354.83

GOT1 inhibitor-1 (compound 2c), a tryptamine-based derivative, acts as a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC 50 of 8.2 uM. GOT1 plays an important role in energy metabolism and Reactive Oxygen Species (ROS) balance. GOT1 inhibitor-1 can be used for the research of pancreatic ductal adenocarcinoma (PDAC) [1] .

O=C(N1CCN(C2=CC=CC3=C2C=CN3)CC1)NC4=CC=C(Cl)C=C4

-20°C

12352200