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ProductsBack/GPI 15427 [805242-85-7]

GPI 15427 [805242-85-7]

HY-15048
MedChem Express
CAS Number805242-85-7
Product group Chemicals
Molecular Weight348.40
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Overview

  • Supplier
    MedChem Express
  • Product Name
    GPI 15427 [805242-85-7]
  • Delivery Days Customer
    5
  • CAS Number
    805242-85-7
  • Certification
    Research Use Only
  • Molecular Formula
    C20H20N4O2
  • Molecular Weight
    348.40
  • Scientific Description
    GPI 15427 is a potent inhibitor of the enzyme poly (ADP-ribose) polymerase-1 (PARP-1), which plays a harmful role during inflammation. In a rat model of gut injury and inflammation, including splanchnic artery occlusion (SAO) shock and dinitrobenzene sulfonic acid (DNBS)-induced colitis, GPI 15427 demonstrated strong anti-inflammatory effects. It reduced inflammatory cell infiltration, histological injury, and delayed clinical signs of inflammation. GPI 15427 also diminished the accumulation of poly (ADP-ribose) in the ileum and colon of treated rats. These results suggest GPI 15427 could be useful for treating intestinal ischemia and inflammation[1].
  • SMILES
    O=C1NN=C2C3=C(OC4=CC=C(CN5CCN(C)CC5)C=C42)C=CC=C31
  • UNSPSC
    12131703

MSDS

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