Gramicidin S

Biorbyt

Gramicidin S [113-73-5]

10

113-73-5

Research Use Only

C60H92N12O10

1141.44688

Gramicidin S is an anttiboitics. Gramicidin S reduces the cell number of planktonic cells within 20-40 min at a concentration of 40-80 microg/mL. Gramicidin S kills the cells of pre-grown biofilms at concentrations of 100-200 microg/mL, such that no re-growth is possible. The translocation of the peptide into the cell interior and its complexation with intracellular nucleotides, including the alarmon ppGpp, can explain its anti-biofilm effect. The successful treatment of persistently infected root canals of two volunteers confirms the high effectiveness of GS. The broad Gramicidin S activity towards resistant, biofilm-forming E. faecalis suggests its applications for approval in root canal medication.

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