Grazoprevir hydrate

MedChem Express

Grazoprevir hydrate [1350462-55-3]

10

1350462-55-3

Research Use Only

99.99

C38H52N6O10S

784.92

Grazoprevir hydrate (MK-5172 hydrate) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K i s of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively [1] [2] . Grazoprevir hydrate inhibits SARS-CoV-2 3CL pro activity [3] .

COC1=CC2=C(N=C(CCCCC[C@@H]3C[C@H]3OC4=O)C(O[C@H]5CN(C([C@H](C(C)(C)C)N4)=O)[C@H](C(N[C@@]([C@@H]6C=C)(C6)C(NS(C7CC7)(=O)=O)=O)=O)C5)=N2)C=C1.O

-20°C,2°C to 8°C

12352200