Bio-Connect

GREM2 antibody [C1C3]

GTX108414
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Rat
TargetGREM2
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Overview

  • Supplier
    GeneTex
  • Product Name
    GREM2 antibody [C1C3]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.26 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID64388
  • Target name
    GREM2
  • Target description
    gremlin 2, DAN family BMP antagonist
  • Target synonyms
    CKTSF1B2; cysteine knot superfamily 1, BMP antagonist 2; DAN domain family member 3; DAND3; gremlin 2, cysteine knot superfamily, homolog; gremlin-2; PRDC; protein related to DAN and cerberus; STHAG9
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ9H772
  • Protein Name
    Gremlin-2
  • Scientific Description
    This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq]
  • Reactivity
    Human, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Triosephosphate isomerase of Streptococcus pneumoniae is released extracellularly by autolysis and binds to host plasminogen to promote its activation. Hirayama S et al., 2022 Jun, FEBS Open Bio
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  • Gremlin 2 suppresses differentiation of stem/progenitor cells in the human skin. Kawagishi-Hotta M et al., 2021 Dec, Regen Ther
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  • Increase of gremlin 2 with age in human adipose-derived stromal/stem cells and its inhibitory effect on adipogenesis. Kawagishi-Hotta M et al., 2019 Dec, Regen Ther
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  • Coordinated Proliferation and Differentiation of Human-Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells Depend on Bone Morphogenetic Protein Signaling Regulation by GREMLIN 2. Bylund JB et al., 2017 May 1, Stem Cells Dev
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  • Effects of gremlin-2 on the transition of primordial follicles during early folliculogenesis in the human ovary. Ikeda Y et al., 2016 Aug, Eur J Obstet Gynecol Reprod Biol
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