GRP78 Antibody: PerCP

Biorbyt

GRP78 antibody

16

0.5 microg/ml of SMC-195 was sufficient for detection of Grp78 in 10 microg of rat tissue lysate by ECL immunoblot analysis.

ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry

WB (1:2000), ICC/IF (1:100) ELISA, ICC, IF, IHC, WB

Research Use Only

Monoclonal

1H11-1H7

1 mg/ml

PerCP

Hspa5

heat shock protein 5

78 kDa glucose-regulated protein; 78kD; AL022860; AU019543; B; baffl; baffled; binding-immunoglobulin protein; Bip; D2Wsu141; D2Wsu141e; D2Wsu17; D2Wsu17e; endoplasmic reticulum chaperone BiP; glucose regulated protein, 78 kDa; Grp; Grp78; GRP-78; heat shock 70 kDa protein 5; heat shock 70kD protein 5 (glucose-regulated protein, 78kD); heat shock protein 70 family protein 5; heat shock protein family A member 5; Hsce7; Hsce70; HSP70 family protein 5; immunoglobulin heavy chain-binding protein; mB; mBiP; Sez; Sez7; SEZ-7; XAP-1 antigen

Mouse

IgG2b

Endoplasmic reticulum chaperone BiP

Mouse monoclonal to GRP78 (PerCP). GRP78 is a ubiquitously expressed, 78-kDa glucose- regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the proper folding and assembly of nascent protein and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5 non-translated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed. GRP78 is also critical for maintenance of cell homeostasis and the prevention of apoptosis. Lou et al. have provided findings that suggest GRP78 is essential for embryonic cell growth and pluripotent cell survival. In terms of diseases, GRP78 has been shown to be a reliable biomarker of hypoglycemia, to serve a neuroprotective function in neurons exposed to glutamate and oxidative stress, and its protein levels are reduced in the brains of Alzheimers patients. Also, the induction of the GRP78 protein that results in severe glucose and oxygen deprivation could possible lead to drug resistance to anti-tumor drugs ..

Amphibian, Bovine, Fungus, Hamster, Human, Monkey, Mouse, Plant, Rabbit, Rat

See Manual

12352203