GSK-25

MedChem Express

GSK-25 [874119-56-9]

10

874119-56-9

Research Use Only

99.68

C24H16Cl2F2N6O

513.33

GSK-25 is a potent, selective and orally bioavailable ROCK1 inhibitor (IC50=7 nM). GSK-25 maintains good selectivity against a panel of 31 kinases (>100 fold), as well as RSK1 and p70S6K (RSK1: IC50=398 nM, p70S6K: IC50=1 microM). GSK-25 inhibits P450 profile (IC50s of 2.5, 5.2, 2.5 microM for CYP2C9, CYP2D6, CYP3A4, respectively)[1].

ClC1=CC(C2=NC(C3=C(F)C=C(Cl)C=C3)C(C(NC4=C(F)C=C(NN=C5)C5=C4)=O)=C(C)N2)=CC=N1

-20°C,2°C to 8°C

12352200