GSK-3 inhibitor 4 [2227279-83-4]
HY-154852
CAS Number2227279-83-4
Product group Chemicals
Estimated Purity98.77
Molecular Weight403.38
Overview
- SupplierMedChem Express
- Product NameGSK-3 inhibitor 4 [2227279-83-4]
- Delivery Days Customer14
- CAS Number2227279-83-4
- CertificationResearch Use Only
- Estimated Purity98.77
- Molecular FormulaC22H15F2N5O
- Molecular Weight403.38
- Scientific DescriptionGSK-3 inhibitor 4 is an orally active and brain-penetrant inhibitor of GSK-3, CDK2, and CDK5, with IC50 values of 0.56 nM (GSK-3beta), 0.45 nM (GSK-3alpha), 0.47 microM, and 0.68 microM, respectively. GSK-3 inhibitor 4 effectively reduces the phosphorylation level of Tau protein. GSK-3 inhibitor 4 can be used in Alzheimers disease (AD) studies[1].
- SMILESO=C(C1=NC(NC2=CC=C(C=C2)F)=NC=C1)NC3=C(C4=CC=C(F)C=C4)C=CN=C3
- Storage Instruction-20°C
- UNSPSC12352200