GSK 3008348 [1629249-33-7]

MedChem Express

GSK 3008348 [1629249-33-7]

9

1629249-33-7

Research Use Only

98.04

C29H37N5O2

487.64

GSK 3008348 is a small molecule antagonist of integrin alphavbeta6 with IC50 values for alphavbeta6, alphavbeta1, alphavbeta3, alphavbeta5, and alphavbeta8 are 1.50, 2.83, 12.53, 4.00, and 2.26 nM, respectively. GSK 3008348 can target the alphavbeta6 integrin, inhibit TGF-beta activation, and thereby alleviate the fibrotic process. GSK 3008348 prevents the binding of the foot-and-mouth disease virus (FMDV) to the alphavbeta6 integrin receptor on the surface of host cells, thereby inhibiting the entry of the virus. GSK 3008348 can be used for research on pulmonary fibrosis and various types of cancer[1][2][3][4].

O=C(O)C[C@@H](C1=CC(N2N=C(C)C=C2C)=CC=C1)CN3C[C@H](CCC(N4)=CC=C5C4=NCCC5)CC3

-20°C,2°C to 8°C

12352200