GSK-340

MedChem Express

GSK-340

5

Research Use Only

C26H31N3O2

417.54

GSK-340 is a BET inhibitor with high affinity and significant selectivity for BD2 from BRD4 with a pIC50 of 7.2. GSK-340 inhibits MCP-1 release in Lipopolysaccharide (HY-D1056) treated PBMCs and whole blood with the pIC50 of 7.4 and 6.0, respectively. GSK-340 has immunomodulatory activity[1].

CC(N1[C@@H](C2CC2)CN(CC3=CC=CC=C3CO)C4=C1C=CC(C5=CCNCC5)=C4)=O

12352200