GSK-3685032

MedChem Express

GSK-3685032 [2170137-61-6]

10

2170137-61-6

Research Use Only

99.95

C22H24N6OS

420.53

GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1 -selective inhibitor, with an IC 50 of 0.036 microM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition [1] .

N#CC1=C(SC(C2=CC=CC=C2)C(N)=O)N=C(N3CCC(CC3)N)C(C#N)=C1CC

-20°C,2°C to 8°C

12352200