GSK-3beta inhibitor 13

MedChem Express

GSK-3beta inhibitor 13 [2227316-74-5]

10

Research Use Only

99.74

C23H22N6O2

414.46

GSK-3beta inhibitor 13 (compound 47) is an orally active and potent GSK-3beta inhibitor with blood-brain permeability. GSK-3beta inhibitor 13 inhibits GSK-3beta and GSK-3alpha with IC50s of 0.73 nM and 0.35 nM, respectively. GSK-3beta inhibitor 13 significantly decreases the phosphorylation of tau (IC50=58 nM), which leads the formation of the neurofibrillary tangles associated with Alzheimers disease[1].

O=C(C1=CC=NN2C1=NC(C3=CC=CC=C3)=C2)NC4=C(C=CN=C4)N5CCOC(C5)C

-20°C,2°C to 8°C

12131703