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GSK-843 [1601496-05-2]

GSK-843 [1601496-05-2]

T11474
TargetMol Chemicals
CAS Number1601496-05-2
DownloadMSDS
Product group Chemicals
Estimated Purity99.18%
Molecular Weight377.49
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    GSK-843 [1601496-05-2]
  • Delivery Days Customer
    10
  • CAS Number
    1601496-05-2
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    GSK-843
  • Estimated Purity
    99.18%
  • Molecular Formula
    C19H15N5S2
  • Molecular Weight
    377.49
  • Scientific Description
    GSK-843 (GSK843) is a selective and potent RIP3 inhibitor with an IC50 value of 8.6 nM for the structural domain of RIP3 kinase. It has potential analgesic activity, inhibits the expression of RIP3 and NLRP3 in the SDH of CFA mice, and can be used as adjunctive therapy for treating inflammation.
  • Shelf life instruction
    3 years
  • SMILES
    Cc1cc(-c2cnc(N)c3c(csc23)-c2ccc3scnc3c2)n(C)n1
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. Kaiser WJ et al., 2013 Oct 25, J Biol Chem
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