GSK-872 (hydrochloride)

MedChem Express

GSK-872 (hydrochloride) [2703752-81-0]

5

2703752-81-0

Research Use Only

99.21

C19H18ClN3O2S2

419.95

GSK-872 hydrochloride is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC 50 of 1.8 nM, and inhibits kinase activity with an IC 50 of 1.3 nM. GSK-872 hydrochloride decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury [1] [2] [3] .

O=S(C1=CC=C2N=CC=C(C2=C1)NC3=CC=C4SC=NC4=C3)(C(C)C)=O.[H]Cl

2°C to 8°C

12352200