GSK-J4 (hydrochloride) (Standard) [1797983-09-5]

MedChem Express

GSK-J4 (hydrochloride) (Standard) [1797983-09-5]

999

Research Use Only

GSK-J4 (hydrochloride) (Standard) is the analytical standard of GSK-J4 (hydrochloride). This product is intended for research and analytical applications. GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 microM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-alpha production in human primary macrophages with an IC50 of 9 microM. GSK-J4 hydrochloride is a cell permeable proagent of GSK-J1[1][2][3].

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