GSK-J4 (Standard) [1373423-53-0]

MedChem Express

GSK-J4 (Standard) [1373423-53-0]

999

Research Use Only

GSK-J4 (Standard) is the analytical standard of GSK-J4. This product is intended for research and analytical applications. GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 microM, respectively. GSK-J4 inhibits LPS-induced TNF-alpha production in human primary macrophages with an IC50 of 9 microM. GSK J4 is a cell permeable proagent of GSK-J1[1][2][3]. GSK-J4 induces endoplasmic reticulum stress-related apoptosis[4].

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