GSK1034702 [932373-87-0]

MedChem Express

GSK1034702 [932373-87-0]

10

932373-87-0

Research Use Only

98.78

C18H24FN3O2

333.40

GSK1034702 is an orally active and allosteric agonist of M1 mAChR (pEC50=8.1) that can cross the blood-brain barrier. GSK1034702 activates the Gq/11 protein-mediated signaling pathway, enhancing neuronal firing and long-term potentiation (LTP) in the CA1 region of the hippocampus. GSK1034702 can modulate hippocampal function, improve memory encoding in the nicotine withdrawal cognitive dysfunction model, and show pro-cognitive effects in rodents. GSK1034702 can be used for the study of the mechanisms of cognitive impairment diseases such as Alzheimers disease, and has certain peripheral M receptor activation-related side effects (such as gastrointestinal reactions)[1][2].

CC1=CC2=C(NC(N2C3CCN(C4CCOCC4)CC3)=O)C(F)=C1

-20°C,2°C to 8°C

12352200