GSK1034702 (hydrochloride) [932373-86-9]
HY-107111A
CAS Number932373-86-9
Product group Chemicals
Molecular Weight369.86
Overview
- SupplierMedChem Express
- Product NameGSK1034702 (hydrochloride) [932373-86-9]
- Delivery Days Customer9
- CAS Number932373-86-9
- CertificationResearch Use Only
- Molecular FormulaC18H25ClFN3O2
- Molecular Weight369.86
- Scientific DescriptionGSK1034702 hydrochloride is an orally active and allosteric agonist of M1 mAChR (pEC50=8.1) that can cross the blood-brain barrier. GSK1034702 hydrochloride activates the Gq/11 protein-mediated signaling pathway, enhancing neuronal firing and long-term potentiation (LTP) in the CA1 region of the hippocampus. GSK1034702 hydrochloride can modulate hippocampal function, improve memory encoding in the nicotine withdrawal cognitive dysfunction model, and show pro-cognitive effects in rodents. GSK1034702 hydrochloride can be used for the study of the mechanisms of cognitive impairment diseases such as Alzheimers disease, and has certain peripheral M receptor activation-related side effects (such as gastrointestinal reactions)[1][2].
- SMILESO=C1NC2=C(C=C(C)C=C2N1C3CCN(C4CCOCC4)CC3)F.Cl
- UNSPSC12352200