GSK180

MedChem Express

GSK180 [1799725-26-0]

10

1799725-26-0

Research Use Only

99.04

C10H7Cl2NO4

276.07

GSK180 is a selective, competitive, and potent inhibitor of kynurenine-3-monooxygenase (KMO) , a key enzyme of tryptophan metabolism ( IC 50 , ~6 nM), but shows negligible activity against other enzymes on the tryptophan pathway. GSK180 rapidly changes levels of kynurenine pathway metabolites, and acts as a useful tool to probe the therapeutic potential of KMO inhibition [1] .

O=C(O)CCN1C(OC2=CC(Cl)=C(Cl)C=C12)=O

-20°C,2°C to 8°C

12352200