GSK2163632A [1123163-20-1]

MedChem Express

GSK2163632A [1123163-20-1]

5

1123163-20-1

Research Use Only

C27H32N8O3S

548.66

GSK2163632A is a selective G protein-coupled receptor kinase (GRK) inhibitor that can be used as a probe for studying heart failure and Parkinsons disease. GSK2163632A potently inhibits GRK1 and GRK5, and also inhibits Rho-associated coiled-coil kinase (ROCK) and insulin-like growth factor receptor IGF-1R. GSK2163632A binds to GRK2 in a manner similar to Paroxetine (HY-122272).

O=C(N)C1=C(C=CS1)NC2=C3C(NC=C3)=NC(NC4=CC5=C(C(C)(CCN5C(CN(C)C)=O)C)C=C4OC)=N2

12352200