GSK2193874
M10625
CAS Number1336960-13-4
Product group Chemicals
Molecular Weight691.62
Overview
- SupplierAbMole BioScience
- Product NameGSK2193874
- Delivery Days Customer9
- CAS Number1336960-13-4
- CertificationResearch Use Only
- Molecular FormulaC37H38BrF3N4O
- Molecular Weight691.62
- Scientific DescriptionGSK2193874 is a first-in-class orally bioavailable potent antagonist of TRPV4 channels, blocking the influx of calcium induced by the TRPV4 agonist with IC50 values of 2, 5, and 40 nM. GSK2193874 is the first-in-class orally bioavailable TRPV4 inhibitor that demonstrated ability to improve pulmonary functions in a number of heart failure models.
- SMILESFC(F)(F)C1=CC=CC(=C1)C2=NC3=CC(=CC=C3C(=C2CN4CCC(CC4)N5CCCCC5)C(=O)NC6(CC6)C7=CC=CC=C7)Br
- UNSPSC12352200
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