GSK2194069

MedChem Express

GSK2194069 [1332331-08-4]

10

1332331-08-4

Research Use Only

99.84

C25H24N4O3

428.48

GSK2194069 is a potent inhibitor of beta-ketoyl reductase ( KR ) of fatty acid synthase ( FASN ), with an IC 50 value of 7.7 nM. GSK2194069 shows specifically inhibitory effect on FAS expressing cancer cells, by acting potent efficacy on acetoacetyl-CoA, NADPH with IC 50 or K i values of 4.8 nM and 5.6 nM, respectively [1] [2] [3] .

O=C(N1C[C@H](CC2=NNC(N2C3=CC=C(C4=CC=C(OC=C5)C5=C4)C=C3)=O)CC1)C6CC6

-20°C,2°C to 8°C

12352200